Product Overview
The Bruker HYPERION II represents a paradigm shift in molecular microscopy, offering the world’s first hybrid platform that seamlessly combines Fourier Transform Infrared (FT-IR) and Quantum Cascade Laser (QCL) technology. This dual-source capability allows researchers to utilize the comprehensive spectral range of FT-IR for broad material identification while leveraging the incredible speed and high-brightness of QCL for targeted chemical imaging. Designed for the most demanding research environments, the HYPERION II bridges the gap between routine analysis and pioneering discovery in material science, pharmaceuticals, and life sciences.
A standout application for this platform is IR-guided MALDI imaging, a multimodal workflow that optimizes spatial biology research. By using the HYPERION II to rapidly scan tissue sections and identify specific chemical signatures, researchers can precisely guide subsequent MALDI-TOF imaging to the most relevant regions of interest. This approach significantly increases laboratory throughput and ensures that high-resolution mass spectrometry is focused where it provides the most biological insight. With an automated sample stage, "Adaptive Chemical Imaging" evaluation, and a fully enclosed Class 1 laser safety system, the HYPERION II is the definitive choice for high-end analytical laboratories.
Product Demonstration
Key Features
- Hybrid Imaging Architecture: Seamlessly switches between proven FT-IR spectroscopy and cutting-edge QCL technology within a single workstation.
- Exceptional Spatial Resolution: Achieves ultra-sharp diffraction-limited resolution, reaching down to 0.2 µm in ATR mode using the QCL module.
- Ultrafast Data Acquisition: Capable of imaging large areas at speeds up to 6.4 mm² per second, dramatically reducing the time required for complex mapping.
- Multimodal Integration: Ideally suited for IR-guided MALDI imaging workflows to streamline spatial biology and pathology research.
- Versatile Detector Suite: Supports a wide range of detectors, including LN-MCT, FPA, and high-speed Microbolometers for simultaneous acquisition of up to 90,000 spectra.
- Research-Grade Automation: Features a motorized X,Y,Z-stage with 0.1 µm step size and software-controlled knife-edge apertures for maximum precision.
- Full Regulatory Compliance: Meets all requirements for cGMP/GLP and FDA 21 CFR Part 11, including automated OQ/PQ validation routines.
Specifications
| FPA Imaging Speed | 0.1 mm²/s |
| ILIM Imaging Speed | 6.4 mm²/s |
| Spatial Resolution (ATR) | QCL: 0.2 µm / FPA: 0.5 µm / LN-MCT: 5 µm |
| Software interface | OPUS with integrated Python interface for custom algorithms |