Game-Changing Through-Barrier Chemical Analysis Products from Cobalt Light
Cobalt Light Systems
Kaplan Scientific has complemented it’s product portfolio with the unique solutions provided by UK company, Cobalt Light Systems.
Cobalt’s proprietary technologies use novel variants of Raman spectroscopy to rapidly and accurately identify materials hidden inside objects or through opaque containers and packaging; and for quantitative analysis of tablet and capsule ingredients in pharmaceutical end product testing.
Cobalt’s products are applied in a range of applications, including:
- Pharmaceutical quantitative analysis of tablets and capsules
- Raw materials ID verification of pharmaceutical incoming goods
- Handheld detection of hazardous chemicals, explosives and narcotics
- Airport security screening of liquids, aerosols and gels
- Non-invasive biological analysis, including screening humans for diseases such as osteoporosis and breast cancer
Cobalt’s Innovative Technologies
Spatially Offset Raman Spectroscopy (SORS™) is a unique way to analyse objects when the contents is behind non-transparent layers or container materials.
SORS works through many millimetres of material, enabling accurate chemical analysis through barriers such as paper, glass, plastic, fabric and skin. The method requires no prior knowledge of the container/surface material and does not require direct physical contact.
Cobalt’s SORS products:
- Resolve™ – Handheld through-barrier hazardous and contraband material ID for Hazmat, EOD and law enforcement
- RapID™ – Raw materials ID verification in pharmaceutical quality control
- Insight200M™ – Screening containers for liquid explosives in airport security checks
Transmission Raman spectroscopy (TRS) is an ideal method for quantitative analysis of mixtures such as tablets, capsules, powders, liquids and suspensions.
Transmission Raman spectroscopy probes the whole content through ≥10mm of sample. The TRS method works by illuminating the sample on one side and collecting the transmitted light on the other. The resulting transmission Raman spectrum is highly representative of the entire sample mixture, enabling sensitive, accurate and fast quantitative measurement of the whole object in one quick measurement.
TRS is an alternative to HPLC for Content Uniformity (CU) analysis that has many attractive benefits, and is increasingly being used by pharmaceutical manufacturers for CU testing.
Cobalt’s TRS product:
The TRS100™ enables fast, easy to use content uniformity & polymorph analysis for regulated pharmaceutical testing.
Products
Resolve
Handheld Through-Barrier Identification
Resolve is the world’s only handheld Raman system that enables true through-barrier identification of hazardous or contraband materials. Resolve rapidly detects and identifies materials from comprehensive libraries including explosives, precursors, toxic industrial chemicals, chemical warfare agents and narcotics.
Can your handheld spectrometer do this?
Resolve enables operators to ID materials without opening or moving the container. Hazards remain contained allowing response teams to make better decisions early in an operation, prior to escalation.
The system is fast, accurate, ruggedized and simple to use – The user simply chooses the container type and the system then determines which measurement mode to use;
Through-Barrier, Surface Scan (traditional point-and-shoot) or Vial Holder.
Through-barrier ID means time spent in protective gear is reduced or used more efficiently.
Measurements take about 1 minute (or less in some modes of operation), with no sample preparation or consumables needed.
RapID
A revolutionary portable raman for verifying pharmaceutical materials through unopened sacks, bottles, coloured glass and plastic containers.
RapID™ is the next generation in portable Raman raw materials ID verification, extending high-throughput spectroscopic identification through clear packaging to non-transparent and coloured containers – even multi-layer paper and plastic sacks.
Raw materials identification faces ever-increasing regulatory pressure for pharmaceutical manufacturing, with 100% testing of containers being desirable or essential.
The impact on cost and resources of increasing the number of containers tested is significant.
Raw materials are received in sacks, tubs, bottles, jars, flexible intermediate bulk containers (FIBCs), plastic drums, barrels, metal or other containers. Most of these are not amenable to traditional spectroscopy as they need to be substantially transparent; for example, thin polyethylene sacks.
Solution: don’t open the packaging
The solution is to avoid sampling the container altogether. Cobalt’s RapID instrument performs Raman ID verification through unopened, non-transparent packaging for most common raw materials.
By removing the sampling process, the ID can be performed by warehouse staff in five to 20 seconds, immediately after receipt of the goods.
TRS100
fast, easy to use content uniformity & polymorph analysis for regulated pharmaceutical testing
Cobalt Light Systems’ TRS100 transmission Raman system is the next generation in real-time non-destructive content uniformity measurement.
Simple to use, the TRS100’s automated analysis replaces laborious HPLC-based methods for solid dosage forms. Easier to implement than other spectroscopic techniques.
The TRS100 allows rapid, accurate quantitative analysis of tablets, capsules, powders and other dosage forms with no sample preparation. Intact tablets or capsules are loaded on to a flexible sample-handling system and individually scanned by our transmission Raman system in less than one second per sample.
With results in seconds, not minutes or even hours, Cobalt’s TRS100 reduces testing resource to decrease release time and improve product quality.